loading...| Preferred Name |
cyproheptadine hydrochloride |
|
| Synonyms |
Periactin |
|
| Definitions |
The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28949" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28949" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000315774 |
|
| altLabel |
Periactin |
|
| cui |
C0031017 C0354872 |
|
| DATE FIRST PUBLISHED |
2003-06-23 |
|
| Date last modified |
2007-02-08 |
|
| definition |
The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties. Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28949" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28949" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28949 |
|
| notation |
CDR0000315774 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
cyproheptadine hydrochloride |
|
| tui |
T109 T121 |