loading...| Preferred Name |
rasburicase |
|
| Synonyms |
SR-29142 |
|
| Definitions |
A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisae. Urate oxidase catalyzes the oxidation of uric acid to the excretable mebolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2404" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2404" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000299001 |
|
| altLabel |
SR-29142 SR 29142 Elitek Urate Oxidase recombinant urate oxidase NK-631 SR29142 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000373867 |
|
| cui |
C0041931 C1812640 C1170248 C0937932 C0338290 |
|
| DATE FIRST PUBLISHED |
2003-03-24 |
|
| Date last modified |
2006-09-11 |
|
| definition |
A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisae. Urate oxidase catalyzes the oxidation of uric acid to the excretable mebolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2404" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2404" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C2404 |
|
| notation |
CDR0000299001 |
|
| NSC Code |
721631 671264 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
rasburicase |
|
| tui |
T116 T126 T121 |