loading...| Preferred Name |
ziconotide |
|
| Synonyms |
Prialt |
|
| Definitions |
A synthetic, nonopiod, twenty-five amino acid polybasic peptide analogue of an omega-conotoxin derived from the marine snail Conus magus with analgesic activity. Ziconotide appears to block neuronal N-type voltage-sensitive calcium channels (NCCB), inhibiting transmission from pain-sensing primary nociceptors. This agent may exhibit significant analgesic activity in refractory pain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1475" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1475" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042866 |
|
| altLabel |
Prialt SNX-111 SNX 111 |
|
| cui |
C0211011 C1530575 C0211013 |
|
| Date last modified |
2008-07-08 |
|
| definition |
A synthetic, nonopiod, twenty-five amino acid polybasic peptide analogue of an omega-conotoxin derived from the marine snail Conus magus with analgesic activity. Ziconotide appears to block neuronal N-type voltage-sensitive calcium channels (NCCB), inhibiting transmission from pain-sensing primary nociceptors. This agent may exhibit significant analgesic activity in refractory pain. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1475" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1475" NCI Thesaurus) |
|
| Legacy PDQ ID |
6676 |
|
| LT |
TRD |
|
| NCI ID |
C1475 |
|
| notation |
CDR0000042866 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ziconotide |
|
| tui |
T109 T116 T121 |