Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

anastrozole

Synonyms

ICI-D1033

Definitions

A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42540&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42540&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1607" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042540

altLabel

ICI-D1033

Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile

ZD-1033

Arimidex

2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)

ANAS

CAS Registry

120511-73-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000371901

http://purl.bioontology.org/ontology/PDQ/CDR0000321914

http://purl.bioontology.org/ontology/PDQ/CDR0000445425

http://purl.bioontology.org/ontology/PDQ/CDR0000038369

http://purl.bioontology.org/ontology/PDQ/CDR0000350019

http://purl.bioontology.org/ontology/PDQ/CDR0000258295

cui

C0878174

C0290882

C0290883

C0733865

Date last modified

2006-05-19

definition

A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42540&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42540&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1607" NCI Thesaurus)

Legacy PDQ ID

6187

LT

TRD

NCI ID

C1607

notation

CDR0000042540

NSC Code

719344

ORIG STY

Drug/agent

prefLabel

anastrozole

tui

T109

T121

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http://purl.bioontology.org/ontology/RXNORM/84857 RxNORM CUI
http://purl.bioontology.org/ontology/RXNORM/84857 RxNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/84857 NIH NLM Value Sets LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000007441 National Drug File - Reference Terminology CUI
http://purl.bioontology.org/ontology/SCTSPA/386910003 SNOMED Terminos Clinicos CUI
http://purl.jp/bio/4/id/200906019270193900 Interlinking Ontology for Biological Concepts LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386910003 SNOMED CT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386910003 SNOMED CT LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 Ontology of Drug Neuropathy Adverse Events LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 BioModels Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 Cell Culture Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 Neuro Behavior Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 The Drug-Drug Interactions Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 The Drug Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 Experimental Factor Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_2704 Chemical Entities of Biological Interest Ontology LOOM
http://purl.bioontology.org/ontology/MESH/C090450 Medical Subject Headings CUI
http://purl.bioontology.org/ontology/MESH/C090450 Medical Subject Headings CUI
http://purl.bioontology.org/ontology/MESH/C090450 Medical Subject Headings CUI
http://purl.bioontology.org/ontology/MESH/C090450 Medical Subject Headings CUI
http://purl.bioontology.org/ontology/MESH/C090450 Medical Subject Headings LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C090450 Robert Hoehndorf Version of MeSH LOOM
http://purl.bioontology.org/ontology/SCTSPA/108774000 SNOMED Terminos Clinicos CUI
http://www.co-ode.org/ontologies/galen#Anastrozole Galen Ontology LOOM
http://purl.bioontology.org/ontology/UATC/L02BG03 Anatomical Therapeutic Chemical Classification CUI
http://purl.bioontology.org/ontology/UATC/L02BG03 Anatomical Therapeutic Chemical Classification LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108774000 SNOMED CT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108774000 SNOMED CT LOOM
http://purl.bioontology.org/ontology/RCD/x02UL Read Codes, Clinical Terms Version 3 (CTV3) CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148427 National Drug File - Reference Terminology CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148427 National Drug File - Reference Terminology LOOM
http://www.drugbank.ca/drugs/DB01217 Functional Therapeutic Chemical Classification System LOOM
http://purl.bioontology.org/ontology/VANDF/4020948 Veterans Health Administration National Drug File CUI
http://purl.bioontology.org/ontology/VANDF/4020948 Veterans Health Administration National Drug File LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1607 National Cancer Institute Thesaurus LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1607 National Cancer Institute Thesaurus LOOM
http://purl.bioontology.org/ontology/NDDF/005094 National Drug Data File CUI
http://purl.bioontology.org/ontology/NDDF/005094 National Drug Data File LOOM
http://purl.bioontology.org/ontology/RXNORM/262485 RxNORM CUI
http://purl.bioontology.org/ontology/RCD/heC.. Read Codes, Clinical Terms Version 3 (CTV3) CUI
http://purl.bioontology.org/ontology/RCD/heC.. Read Codes, Clinical Terms Version 3 (CTV3) LOOM