loading...| Preferred Name |
prasterone |
|
| Synonyms |
GL701 Fidelin Dehydroepiandrosterone DHEA 3beta-Hydroxyandrost-5-en-17-one therapeutic dehydroepiandrosterone Dehydroisoandrosterone |
|
| Definitions |
A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2265" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2265" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042419 |
|
| altLabel |
GL701 Fidelin Dehydroepiandrosterone DHEA 3beta-Hydroxyandrost-5-en-17-one therapeutic dehydroepiandrosterone Dehydroisoandrosterone |
|
| CAS Registry |
53-43-0 |
|
| cui |
C1710380 C0011185 C0917987 |
|
| Date last modified |
2010-10-27 |
|
| definition |
A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2265" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2265" NCI Thesaurus) |
|
| Legacy PDQ ID |
5694 |
|
| LT |
TRD |
|
| NCI ID |
C2265 |
|
| notation |
CDR0000042419 |
|
| NSC Code |
9896 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
prasterone |
|
| tui |
T125 T109 T121 |