Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

dehydroepiandrosterone

Synonyms

GL701

Definitions

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42419&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42419&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2265" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042419

altLabel

GL701

Fidelin

Prasterone

Dehydroisoandrosterone

DHEA

3beta-Hydroxyandrost-5-en-17-one

Therapeutic Dehydroepiandrosterone

CAS Registry

53-43-0

cui

C0917987

C1710380

C0011185

Date last modified

2006-08-01

definition

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42419&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42419&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2265" NCI Thesaurus)

Legacy PDQ ID

5694

LT

TRD

NCI ID

C2265

notation

CDR0000042419

NSC Code

9896

ORIG STY

Drug/agent

prefLabel

dehydroepiandrosterone

tui

T125

T109

T121

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