Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

prasterone

Synonyms

GL701

Definitions

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2265" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2265" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042419

altLabel

GL701

therapeutic dehydroepiandrosterone

Fidelin

Dehydroisoandrosterone

DHEA

3beta-Hydroxyandrost-5-en-17-one

Dehydroepiandrosterone

CAS Registry

53-43-0

cui

C0917987

C1710380

C0011185

Date last modified

2010-10-27

definition

A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2265" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2265" NCI Thesaurus)

Legacy PDQ ID

5694

LT

TRD

NCI ID

C2265

notation

CDR0000042419

NSC Code

9896

ORIG STY

Drug/agent

prefLabel

prasterone

tui

T125

T109

T121

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http://purl.bioontology.org/ontology/NDFRT/N0000010096 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148779 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000193467 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000193467 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D003687 MESH CUI
http://purl.bioontology.org/ontology/NDDF/004609 NDDF CUI
http://purl.bioontology.org/ontology/SCTSPA/78316004 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/X80FW RCD CUI
http://purl.bioontology.org/ontology/VANDF/4021360 VANDF CUI
http://purl.bioontology.org/ontology/SNMI/F-B2830 SNMI CUI
http://purl.bioontology.org/ontology/SCTSPA/413963008 SCTSPA CUI
http://purl.bioontology.org/ontology/UATC/G03XX01 ATC CUI
http://purl.bioontology.org/ontology/UATC/G03XX01 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2265 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2265 NCIT LOOM
http://purl.bioontology.org/ontology/SNMI/F-B28B8 SNMI CUI
http://purl.bioontology.org/ontology/UATC/A14AA07 ATC CUI
http://purl.bioontology.org/ontology/UATC/A14AA07 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/78316004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D003687 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/MTHU003476 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP15528-0 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/3143 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/3143 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4036745 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4036745 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/0171-4928 CRISP CUI
http://purl.bioontology.org/ontology/SNOMEDCT/413963008 SNOMEDCT CUI
http://sbmi.uth.tmc.edu/ontology/ochv#3664 OCHV LOOM