loading...| Preferred Name |
acarbose |
|
| Synonyms |
Bay g 5421 |
|
| Definitions |
A pseudotetrasaccharide and inhibitor of alpha-glucosidase and pancreatic alpha-amylase with antihyperglycemic activity. Acarbose binds to and inhibits alpha-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. This prevents the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial blood glucose levels. In addition, acarbose inhibits pancreatic alpha-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C983" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C983" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042140 |
|
| altLabel |
Bay g 5421 Precose O-4,6-dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-D-glucose |
|
| CAS Registry |
56180-94-0 |
|
| cui |
C0752276 C0050393 C0591572 |
|
| Date last modified |
2015-09-03 |
|
| definition |
A pseudotetrasaccharide and inhibitor of alpha-glucosidase and pancreatic alpha-amylase with antihyperglycemic activity. Acarbose binds to and inhibits alpha-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. This prevents the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial blood glucose levels. In addition, acarbose inhibits pancreatic alpha-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C983" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C983" NCI Thesaurus) |
|
| Legacy PDQ ID |
5377 |
|
| LT |
TRD |
|
| NCI ID |
C983 |
|
| notation |
CDR0000042140 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
acarbose |
|
| tui |
T109 T121 |