loading...| Preferred Name |
alteplase |
|
| Synonyms |
Activase |
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C39607" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C39607" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042033 |
|
| altLabel |
Activase t-PA recombinant tissue plasminogen activator rt-PA |
|
| Component of | ||
| cui |
C0032143 C0701942 |
|
| Date last modified |
2010-10-27 |
|
| definition |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C39607" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C39607" NCI Thesaurus) |
|
| Legacy PDQ ID |
5262 |
|
| LT |
TRD |
|
| NCI ID |
C39607 |
|
| notation |
CDR0000042033 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
alteplase |
|
| tui |
T116 T126 T121 |