Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

alteplase

Synonyms

Activase

Definitions

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C39607" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C39607" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042033

altLabel

Activase

t-PA

rt-PA

recombinant tissue plasminogen activator

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000347392

cui

C0032143

C0701942

Date last modified

2010-10-27

definition

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C39607" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C39607" NCI Thesaurus)

Legacy PDQ ID

5262

LT

TRD

NCI ID

C39607

notation

CDR0000042033

ORIG STY

Drug/agent

prefLabel

alteplase

tui

T116

T121

T126

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http://purl.bioontology.org/ontology/NDFRT/N0000147695 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147695 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4019319 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387152000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387152000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNMI/C-A7410 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-A7410 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/8410 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/8410 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/27638005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/F-D7A20 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108997009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/387152000 SCTSPA CUI
http://purl.obolibrary.org/obo/DRON_00010173 DRON LOOM
http://purl.bioontology.org/ontology/NDDF/002074 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002074 NDDF LOOM
http://purl.bioontology.org/ontology/CSP/0437-7160 CRISP CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007047 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4019599 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4019599 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP16891-1 LOINC CUI
http://purl.bioontology.org/ontology/RCD/bv3.. RCD CUI
http://purl.bioontology.org/ontology/RCD/bv3.. RCD LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39607 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/37411004 SNOMEDCT CUI
http://www.co-ode.org/ontologies/galen#Alteplase GALEN LOOM
http://purl.jp/bio/4/id/200906031083763808 IOBC LOOM
http://purl.bioontology.org/ontology/SCTSPA/37411004 SCTSPA CUI
http://purl.bioontology.org/ontology/UATC/S01XA13 ATC CUI
http://purl.bioontology.org/ontology/UATC/S01XA13 ATC LOOM
http://www.drugbank.ca/drugs/DB00009 FTC LOOM
http://purl.bioontology.org/ontology/SCTSPA/27638005 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-C1080 SNMI CUI
http://purl.bioontology.org/ontology/MSHFRE/D010959 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D010959 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147508 NDFRT CUI
http://purl.bioontology.org/ontology/UATC/B01AD02 ATC CUI
http://purl.bioontology.org/ontology/UATC/B01AD02 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU019721 LOINC CUI
http://purl.obolibrary.org/obo/dinto_DB00009 DINTO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9816 OCHV LOOM
http://purl.bioontology.org/ontology/SCTSPA/108997009 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/204210 RXNORM CUI
http://purl.bioontology.org/ontology/MESH/D010959 MESH CUI
http://purl.bioontology.org/ontology/MESH/D010959 MESH CUI
http://sbmi.uth.tmc.edu/ontology/ochv#C0032143 OCHV LOOM