loading...| Preferred Name |
finasteride |
|
| Synonyms |
(5alpha,17beta)-N-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide |
|
| Definitions |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1099" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1099" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041096 |
|
| altLabel |
(5alpha,17beta)-N-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide Finastid Proscar MK 906 Pro-Cure MK-906 Prostide Uprosan Chibro-Proscar |
|
| Component of | ||
| cui |
C1517188 C0060389 C0733735 C0678149 C1831595 C1517192 C1517190 C1517189 |
|
| Date last modified |
2008-10-14 |
|
| definition |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1099" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1099" NCI Thesaurus) |
|
| Legacy PDQ ID |
4136 |
|
| LT |
TRD |
|
| NCI ID |
C1099 |
|
| notation |
CDR0000041096 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
finasteride |
|
| tui |
T125 T109 T121 |