loading...| Preferred Name |
stavudine |
|
| Synonyms |
2',3'-didehydro-3'-deoxythymidine |
|
| Definitions |
A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1428" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1428" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041064 |
|
| altLabel |
2',3'-didehydro-3'-deoxythymidine d4T dideoxydidehydrothymidine 1-(2,3-dideoxy-beta-glycero-pent-2-enofuranosyl)thymine BMY-27857 Zerit didehydrodeoxythymidine 3'-deoxy-2'-thymidinene |
|
| CAS Registry |
3056-17-5 |
|
| Component of | ||
| cui |
C0701313 C0164662 C0701312 |
|
| definition |
A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1428" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1428" NCI Thesaurus) |
|
| Legacy PDQ ID |
4103 |
|
| LT |
TRD |
|
| NCI ID |
C1428 |
|
| notation |
CDR0000041064 |
|
| NSC Code |
163661 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
stavudine |
|
| tui |
T114 T121 |