loading...| Preferred Name |
fluconazole |
|
| Synonyms |
alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol |
|
| Definitions |
A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C500" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C500" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040842 |
|
| altLabel |
alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol FCZ Diflucan |
|
| CAS Registry |
86386-73-4 |
|
| Component of | ||
| cui |
C0699601 C0016277 |
|
| Date last modified |
2006-08-02 |
|
| definition |
A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C500" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C500" NCI Thesaurus) |
|
| Legacy PDQ ID |
3871 |
|
| LT |
TRD |
|
| NCI ID |
C500 |
|
| notation |
CDR0000040842 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
fluconazole |
|
| tui |
T109 T121 |