loading...| Preferred Name |
medroxyprogesterone acetate |
|
| Synonyms |
MPA |
|
| Definitions |
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1155" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1155" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039813 |
|
| altLabel |
MPA Perlutex Lutoral 6-alpha-methyl-17alpha-acetoxyprogesterone G-Farlutal Veramix Sodelut G Depo-Clinovir Gestapuran 17-(acetyloxy)-6alpha-methylpregn-4-ene-3,20-dione Aragest 17-hydroxy-6alpha-methylpregn-4-ene-3,20-dione acetate depot-medroxyprogestereone acetate Farlutal Hysron 17alpha-acetoxy-6alpha-methylprogesterone Amen Ciclotal Clinovir metipregnone Depo-Provera Provera (6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione Prodasone Clinofem |
|
| CAS Registry |
71-58-9 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000040448 http://purl.bioontology.org/ontology/PDQ/CDR0000041475 http://purl.bioontology.org/ontology/PDQ/CDR0000038466 |
|
| cui |
C1513076 C1513074 C0699700 C1513080 C0699702 C0699701 C1513075 C1513072 C0699707 C0305236 C0699706 C0699703 C0025147 C0699708 C1513079 C1513071 C1513073 C1513070 C0065864 |
|
| Date last modified |
2017-11-03 |
|
| definition |
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1155" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1155" NCI Thesaurus) |
|
| Legacy PDQ ID |
249 |
|
| LT |
TRD |
|
| NCI ID |
C1155 |
|
| notation |
CDR0000039813 |
|
| NSC Code |
26386 21171 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
medroxyprogesterone acetate |
|
| tui |
T125 T109 T121 |