Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

warfarin sodium

Synonyms

prothromadin

Definitions

The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1658" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1658" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039740

altLabel

prothromadin

Waran

Warfilone

Coumadin

Marevan

Panwarfin

tintorane

CAS Registry

129-06-6

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000387962

cui

C0699129

C4721510

C1520124

C4721511

C0376218

C0699130

C1520125

Date last modified

2017-11-03

definition

The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1658" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1658" NCI Thesaurus)

Legacy PDQ ID

2401

LT

TRD

NCI ID

C1658

notation

CDR0000039740

ORIG STY

Drug/agent

prefLabel

warfarin sodium

tui

T109

T131

T121

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http://purl.obolibrary.org/obo/CHEBI_10034 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_10034 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10034 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/63167009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/63167009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/202421 RXNORM CUI
http://www.co-ode.org/ontologies/galen#WarfarinSodium GALEN LOOM
http://stirdf.jst.go.jp/id/200907046861145271 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/114194 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/114194 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0376218 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-C2196 SNMI CUI
http://purl.bioontology.org/ontology/CSP/0397-0420 CRISP CUI
http://purl.bioontology.org/ontology/RCD/x02iF RCD CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1658 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1658 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/002085 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002085 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000179501 NDFRT CUI
http://sbmi.uth.tmc.edu/ontology/ochv#31714 OCHV LOOM
http://purl.bioontology.org/ontology/SCTSPA/63167009 SCTSPA CUI
http://purl.jp/bio/4/id/200906033409669907 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146870 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146870 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D014859 MESH CUI
http://purl.bioontology.org/ontology/MESH/D014859 MESH CUI
http://purl.bioontology.org/ontology/RCD/x01O4 RCD CUI
http://purl.bioontology.org/ontology/MSHFRE/D014859 MSHFRE CUI
http://purl.bioontology.org/ontology/SNMI/C-A6531 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-A6531 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4018548 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4018548 VANDF LOOM