loading...| Preferred Name |
warfarin |
| Synonyms |
Athrombin-K |
| Definitions |
A synthetic anticoagulant. Warfarin appears to inhibit the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C945" NCI Thesaurus) |
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039740 |
| altLabel |
Athrombin-K 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one WARF Compound 42 WARF Compound 42 Co-Rax Rodex Coumadin 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin Panwarfin |
| CAS Registry |
81-81-2 |
| Component of | |
| cui |
C0917972 C1520122 C0043031 C0699129 C1527323 C1520121 C0699130 C1520123 |
| Date last modified |
2006-09-28 |
| definition |
A synthetic anticoagulant. Warfarin appears to inhibit the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C945" NCI Thesaurus) |
| Legacy PDQ ID |
2401 |
| LT |
TRD |
| NCI ID |
C945 |
| notation |
CDR0000039740 |
| NSC Code |
59813 |
| ORIG STY |
Drug/agent |
| prefLabel |
warfarin |
| tui |
T109 T131 T121 |