Physician Data Query

Last uploaded: April 29, 2019
Preferred Name

warfarin

Synonyms

Athrombin-K

Definitions

A synthetic anticoagulant. Warfarin appears to inhibit the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C945" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039740

altLabel

Athrombin-K

3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin

4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

WARF

Compound 42

WARF Compound 42

Co-Rax

Rodex

Coumadin

1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone

3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin

Panwarfin

CAS Registry

81-81-2

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000387962

cui

C0917972

C1520122

C0043031

C0699129

C1527323

C1520121

C0699130

C1520123

Date last modified

2006-09-28

definition

A synthetic anticoagulant. Warfarin appears to inhibit the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39740&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C945" NCI Thesaurus)

Legacy PDQ ID

2401

LT

TRD

NCI ID

C945

notation

CDR0000039740

NSC Code

59813

ORIG STY

Drug/agent

prefLabel

warfarin

tui

T109

T131

T121

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http://www.semanticweb.org/席婷/ontologies/2019/3/untitled-ontology-62#Warfarin PCALION LOOM
http://www.semanticweb.org/席婷/ontologies/2019/3/untitled-ontology-62#Warfarin PCALION LOOM
http://stirdf.jst.go.jp/id/200907035077542769 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/11289 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/11289 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_10033 EFO LOOM
http://stirdf.jst.go.jp/id/200907061659150750 IOBC LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Warfarin PCAO LOOM
http://purl.bioontology.org/ontology/RXNORM/202421 RXNORM CUI
http://purl.jp/bio/4/id/200906087586835534 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148057 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148057 NDFRT LOOM
http://www.genomic-cds.org/ont/genomic-cds.owl#Warfarin GENE-CDS LOOM
http://www.co-ode.org/ontologies/galen#Warfarin GALEN LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e4a06e5e_bdd1_49fc_814a_47a41d12ec58 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_e4a06e5e_bdd1_49fc_814a_47a41d12ec58 STO-DRAFT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.150.446.520.914 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/48603004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/MTHU003212 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU003212 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000006403 NDFRT CUI
http://www.drugbank.ca/drugs/DB00682 FTC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0043031 HFO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372756006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/372756006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP16309-4 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP16309-4 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014859 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-A6530 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-A6530 SNMI LOOM
http://purl.bioontology.org/ontology/NDDF/002084 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002084 NDDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-C2196 SNMI CUI
http://purl.bioontology.org/ontology/CSP/0397-0420 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0397-0420 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0397-0420 CRISP LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C945 NCIT LOOM
http://purl.bioontology.org/ontology/RCD/x02iF RCD CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.830.219.446.520.914 RH-MESH LOOM
http://bmi.utah.edu/ontologies/peontology/C0043031 PE LOOM
http://d-nb.info/gnd/4189116-8 FAST-TOPICAL LOOM
http://purl.jp/bio/4/id/200906041207325087 IOBC LOOM
http://id.loc.gov/authorities/subjects/sh87004217 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/LNC/LA28654-4 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LA28654-4 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D014859 MESH CUI
http://purl.bioontology.org/ontology/MESH/D014859 MESH CUI
http://purl.bioontology.org/ontology/MESH/D014859 MESH LOOM
http://purl.jp/bio/4/id/200906089236296382 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019972 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4019972 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/x01O4 RCD CUI
http://purl.bioontology.org/ontology/RCD/x01O4 RCD LOOM
http://stirdf.jst.go.jp/id/200907082204646470 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/B01AA03 ATC CUI
http://purl.bioontology.org/ontology/UATC/B01AA03 ATC LOOM