loading...| Preferred Name |
warfarin sodium |
| Synonyms |
prothromadin |
| Definitions |
The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1658" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1658" NCI Thesaurus) |
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039740 |
| altLabel |
prothromadin Waran Warfilone Coumadin Marevan Panwarfin tintorane |
| CAS Registry |
129-06-6 |
| Component of | |
| cui |
C0699129 C4721510 C1520124 C4721511 C0376218 C0699130 C1520125 |
| Date last modified |
2017-11-03 |
| definition |
The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1658" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1658" NCI Thesaurus) |
| Legacy PDQ ID |
2401 |
| LT |
TRD |
| NCI ID |
C1658 |
| notation |
CDR0000039740 |
| ORIG STY |
Drug/agent |
| prefLabel |
warfarin sodium |
| tui |
T109 T131 T121 |