thiabendazole

MK-360

A benzimidazole derivative with anthelminthic property. Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death. In addition, it has been suggested that thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C873" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C873" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000039713

MK-360

TBZ

Mintezol

Thibenzole

148-79-8

C0039832

C0700007

C0733600

C0733598

A benzimidazole derivative with anthelminthic property. Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death. In addition, it has been suggested that thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C873" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C873" NCI Thesaurus)

2375

TRD

C873

CDR0000039713

90507

Drug/agent

thiabendazole

T109

T121