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A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C412" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C412" NCI Thesaurus)
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actinomycin IV actinomycin-C1 AD Cosmegen actinomycin-D ACT-D 2-bis[cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3 actinomycin D actinomycin I1 meractinomycin dactinomycine actinomycin C1 actinomycin X 1 DACT Lyovac Cosmegen actinomycin-[thr-val-pro-sar-meval]
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