loading...| Preferred Name |
lidocaine hydrochloride |
|
| Synonyms |
Xylocaine Xylocitin Xylotox 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride |
|
| Definitions |
The hydrochloride salt from of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48000" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48000" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039607 |
|
| altLabel |
Xylocaine Xylocitin Xylotox 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide monohydrochloride |
|
| CAS Registry |
6108-05-0 |
|
| cui |
C0699094 C0546869 C0702203 C0592275 |
|
| Date last modified |
2017-11-02 |
|
| definition |
The hydrochloride salt from of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48000" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48000" NCI Thesaurus) |
|
| Legacy PDQ ID |
2262 |
|
| LT |
TRD |
|
| NCI ID |
C48000 |
|
| notation |
CDR0000039607 |
|
| NSC Code |
40030 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
lidocaine hydrochloride |
|
| tui |
T109 T121 |