loading...| Preferred Name |
promethazine hydrochloride |
|
| Synonyms |
phenazine |
|
| Definitions |
The hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C45907" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C45907" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039567 |
|
| altLabel |
phenazine Phencen Anergan prometh Zipan Phenergan Prorex V-Gan Provigan N,N-dimethyl- 1-(10H-phenothiazin-10-yl) propan-2-amine |
|
| CAS Registry |
58-33-3 |
|
| cui |
C4053703 C0546876 C2917617 C0699110 C4053552 C1882481 C4732947 C0722862 C0591971 C2917605 |
|
| Date last modified |
2015-10-15 |
|
| definition |
The hydrochloride salt form of promethazine, a phenothiazine derivative with antihistaminic, sedative and antiemetic properties. Promethazine hydrochloride selectively blocks peripheral H1 receptors thereby diminishing the effects of histamine on effector cells. Promethazine hydrochloride also blocks the central histaminergic receptors, thereby depressing the reticular system causing sedative and hypnotic effects. In addition, promethazine hydrochloride also has centrally acting anticholinergic properties and probably mediates nausea and vomiting by acting on the medullary chemoreceptive trigger zone. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C45907" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C45907" NCI Thesaurus) |
|
| Legacy PDQ ID |
2221 |
|
| LT |
TRD |
|
| NCI ID |
C45907 |
|
| notation |
CDR0000039567 |
|
| NSC Code |
231688 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
promethazine hydrochloride |
|
| tui |
T109 T121 |