loading...| Preferred Name |
imidazole mustard |
|
| Synonyms |
TIC mustard |
|
| Definitions |
A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2216" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2216" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039483 |
|
| altLabel |
TIC mustard 5-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide BIC HN2 |
|
| CAS Registry |
5034-77-5 |
|
| cui |
C0063382 |
|
| Date last modified |
2006-12-21 |
|
| definition |
A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2216" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2216" NCI Thesaurus) |
|
| Legacy PDQ ID |
2117 |
|
| NCI ID |
C2216 |
|
| notation |
CDR0000039483 |
|
| NSC Code |
82196 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
imidazole mustard |
|
| tui |
T109 T121 |