Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

amiodarone hydrochloride

Synonyms

Nexterone

Definitions

The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C236" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C236" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039410

altLabel

Nexterone

Cordarone

CAS Registry

19774-82-4

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041042

http://purl.bioontology.org/ontology/PDQ/CDR0000039419

http://purl.bioontology.org/ontology/PDQ/CDR0000039418

cui

C0700442

C0701076

C2608296

Date last modified

2017-11-02

definition

The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C236" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C236" NCI Thesaurus)

Legacy PDQ ID

2045

LT

TRD

NCI ID

C236

notation

CDR0000039410

NSC Code

85442

ORIG STY

Drug/agent

prefLabel

amiodarone hydrochloride

tui

T109

T121

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http://purl.bioontology.org/ontology/SNMI/C-80351 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-80351 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D000638 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000638 MESH CUI
http://stirdf.jst.go.jp/id/200907018858553004 IOBC LOOM
http://www.co-ode.org/ontologies/galen#AmiodaroneHydrochloride GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4018065 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4018065 VANDF LOOM
http://purl.bioontology.org/ontology/MSHFRE/D000638 MSHFRE CUI
http://sbmi.uth.tmc.edu/ontology/ochv#44764 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/203114 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/203114 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146406 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146406 NDFRT LOOM
http://purl.jp/bio/4/id/200906032028918807 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/000629 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/52574003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/52574003 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_2664 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2664 CHEBI LOOM
http://purl.bioontology.org/ontology/RXNORM/832067 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/203588 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/52574003 SCTSPA CUI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146406 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146406 OCVDAE LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C236 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C236 NCIT LOOM