carboplatin

(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum

A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1282" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1282" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000039176

(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum

Platinwas

Nealorin

platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)

cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II)

Carbosol

Carbosin

Paraplatine

Carbotec

CBDCA

1,1-cyclobutanedicarboxylic acid platinum complex

Carboplatin Hexal

cis-diammine(cyclobutanedicarboxylato)platinum II

Paraplatin AQ

Displata

Carboplat

cis-diammine(cyclobutane-1,1-dicarboxylato)platinum

Ribocarbo

JM-8

Ercar

Blastocarb

Carboplatino

Novoplatinum

41575-94-4

http://purl.bioontology.org/ontology/PDQ/CDR0000041176

http://purl.bioontology.org/ontology/PDQ/CDR0000042898

http://purl.bioontology.org/ontology/PDQ/CDR0000352312

http://purl.bioontology.org/ontology/PDQ/CDR0000041837

http://purl.bioontology.org/ontology/PDQ/CDR0000042131

http://purl.bioontology.org/ontology/PDQ/CDR0000350208

http://purl.bioontology.org/ontology/PDQ/CDR0000270688

http://purl.bioontology.org/ontology/PDQ/CDR0000043150

http://purl.bioontology.org/ontology/PDQ/CDR0000041320

http://purl.bioontology.org/ontology/PDQ/CDR0000041708

http://purl.bioontology.org/ontology/PDQ/CDR0000037923

http://purl.bioontology.org/ontology/PDQ/CDR0000405881

http://purl.bioontology.org/ontology/PDQ/CDR0000041477

http://purl.bioontology.org/ontology/PDQ/CDR0000039335

http://purl.bioontology.org/ontology/PDQ/CDR0000042656

http://purl.bioontology.org/ontology/PDQ/CDR0000042767

http://purl.bioontology.org/ontology/PDQ/CDR0000040857

http://purl.bioontology.org/ontology/PDQ/CDR0000257774

http://purl.bioontology.org/ontology/PDQ/CDR0000038848

http://purl.bioontology.org/ontology/PDQ/CDR0000037781

http://purl.bioontology.org/ontology/PDQ/CDR0000037936

http://purl.bioontology.org/ontology/PDQ/CDR0000042182

http://purl.bioontology.org/ontology/PDQ/CDR0000040895

http://purl.bioontology.org/ontology/PDQ/CDR0000387738

http://purl.bioontology.org/ontology/PDQ/CDR0000335285

http://purl.bioontology.org/ontology/PDQ/CDR0000041580

http://purl.bioontology.org/ontology/PDQ/CDR0000428394

http://purl.bioontology.org/ontology/PDQ/CDR0000042046

http://purl.bioontology.org/ontology/PDQ/CDR0000041248

http://purl.bioontology.org/ontology/PDQ/CDR0000043643

http://purl.bioontology.org/ontology/PDQ/CDR0000041698

http://purl.bioontology.org/ontology/PDQ/CDR0000042353

http://purl.bioontology.org/ontology/PDQ/CDR0000039439

http://purl.bioontology.org/ontology/PDQ/CDR0000038327

http://purl.bioontology.org/ontology/PDQ/CDR0000041283

http://purl.bioontology.org/ontology/PDQ/CDR0000445426

http://purl.bioontology.org/ontology/PDQ/CDR0000043358

http://purl.bioontology.org/ontology/PDQ/CDR0000037973

http://purl.bioontology.org/ontology/PDQ/CDR0000346890

http://purl.bioontology.org/ontology/PDQ/CDR0000038255

http://purl.bioontology.org/ontology/PDQ/CDR0000038204

http://purl.bioontology.org/ontology/PDQ/CDR0000041159

http://purl.bioontology.org/ontology/PDQ/CDR0000269712

http://purl.bioontology.org/ontology/PDQ/CDR0000041006

http://purl.bioontology.org/ontology/PDQ/CDR0000042950

http://purl.bioontology.org/ontology/PDQ/CDR0000042510

http://purl.bioontology.org/ontology/PDQ/CDR0000042167

http://purl.bioontology.org/ontology/PDQ/CDR0000299571

http://purl.bioontology.org/ontology/PDQ/CDR0000038514

http://purl.bioontology.org/ontology/PDQ/CDR0000043452

http://purl.bioontology.org/ontology/PDQ/CDR0000042899

http://purl.bioontology.org/ontology/PDQ/CDR0000407531

http://purl.bioontology.org/ontology/PDQ/CDR0000042181

http://purl.bioontology.org/ontology/PDQ/CDR0000043309

http://purl.bioontology.org/ontology/PDQ/CDR0000038524

http://purl.bioontology.org/ontology/PDQ/CDR0000042924

http://purl.bioontology.org/ontology/PDQ/CDR0000043683

http://purl.bioontology.org/ontology/PDQ/CDR0000042963

http://purl.bioontology.org/ontology/PDQ/CDR0000041582

http://purl.bioontology.org/ontology/PDQ/CDR0000373941

http://purl.bioontology.org/ontology/PDQ/CDR0000041355

http://purl.bioontology.org/ontology/PDQ/CDR0000042414

http://purl.bioontology.org/ontology/PDQ/CDR0000040589

http://purl.bioontology.org/ontology/PDQ/CDR0000041641

http://purl.bioontology.org/ontology/PDQ/CDR0000042023

http://purl.bioontology.org/ontology/PDQ/CDR0000363617

http://purl.bioontology.org/ontology/PDQ/CDR0000042655

http://purl.bioontology.org/ontology/PDQ/CDR0000039367

http://purl.bioontology.org/ontology/PDQ/CDR0000038532

http://purl.bioontology.org/ontology/PDQ/CDR0000043732

http://purl.bioontology.org/ontology/PDQ/CDR0000269304

http://purl.bioontology.org/ontology/PDQ/CDR0000391854

http://purl.bioontology.org/ontology/PDQ/CDR0000042345

http://purl.bioontology.org/ontology/PDQ/CDR0000041256

http://purl.bioontology.org/ontology/PDQ/CDR0000041791

http://purl.bioontology.org/ontology/PDQ/CDR0000038158

http://purl.bioontology.org/ontology/PDQ/CDR0000041003

http://purl.bioontology.org/ontology/PDQ/CDR0000038489

http://purl.bioontology.org/ontology/PDQ/CDR0000357521

http://purl.bioontology.org/ontology/PDQ/CDR0000040897

http://purl.bioontology.org/ontology/PDQ/CDR0000041445

http://purl.bioontology.org/ontology/PDQ/CDR0000042569

http://purl.bioontology.org/ontology/PDQ/CDR0000041264

http://purl.bioontology.org/ontology/PDQ/CDR0000373863

http://purl.bioontology.org/ontology/PDQ/CDR0000041610

http://purl.bioontology.org/ontology/PDQ/CDR0000041230

http://purl.bioontology.org/ontology/PDQ/CDR0000041208

http://purl.bioontology.org/ontology/PDQ/CDR0000043229

http://purl.bioontology.org/ontology/PDQ/CDR0000043089

http://purl.bioontology.org/ontology/PDQ/CDR0000041255

http://purl.bioontology.org/ontology/PDQ/CDR0000043068

http://purl.bioontology.org/ontology/PDQ/CDR0000041377

http://purl.bioontology.org/ontology/PDQ/CDR0000331865

http://purl.bioontology.org/ontology/PDQ/CDR0000038444

http://purl.bioontology.org/ontology/PDQ/CDR0000041675

http://purl.bioontology.org/ontology/PDQ/CDR0000042514

http://purl.bioontology.org/ontology/PDQ/CDR0000041869

http://purl.bioontology.org/ontology/PDQ/CDR0000042498

http://purl.bioontology.org/ontology/PDQ/CDR0000041962

http://purl.bioontology.org/ontology/PDQ/CDR0000257847

http://purl.bioontology.org/ontology/PDQ/CDR0000357573

http://purl.bioontology.org/ontology/PDQ/CDR0000042082

http://purl.bioontology.org/ontology/PDQ/CDR0000042085

http://purl.bioontology.org/ontology/PDQ/CDR0000038059

http://purl.bioontology.org/ontology/PDQ/CDR0000038003

http://purl.bioontology.org/ontology/PDQ/CDR0000041376

http://purl.bioontology.org/ontology/PDQ/CDR0000038638

http://purl.bioontology.org/ontology/PDQ/CDR0000041699

http://purl.bioontology.org/ontology/PDQ/CDR0000037924

http://purl.bioontology.org/ontology/PDQ/CDR0000043247

http://purl.bioontology.org/ontology/PDQ/CDR0000041373

http://purl.bioontology.org/ontology/PDQ/CDR0000038368

http://purl.bioontology.org/ontology/PDQ/CDR0000040296

http://purl.bioontology.org/ontology/PDQ/CDR0000041352

http://purl.bioontology.org/ontology/PDQ/CDR0000041094

http://purl.bioontology.org/ontology/PDQ/CDR0000346888

http://purl.bioontology.org/ontology/PDQ/CDR0000042602

http://purl.bioontology.org/ontology/PDQ/CDR0000041359

http://purl.bioontology.org/ontology/PDQ/CDR0000041203

http://purl.bioontology.org/ontology/PDQ/CDR0000042065

http://purl.bioontology.org/ontology/PDQ/CDR0000041620

http://purl.bioontology.org/ontology/PDQ/CDR0000038108

http://purl.bioontology.org/ontology/PDQ/CDR0000041982

http://purl.bioontology.org/ontology/PDQ/CDR0000038348

http://purl.bioontology.org/ontology/PDQ/CDR0000335286

http://purl.bioontology.org/ontology/PDQ/CDR0000038694

http://purl.bioontology.org/ontology/PDQ/CDR0000043466

http://purl.bioontology.org/ontology/PDQ/CDR0000040464

http://purl.bioontology.org/ontology/PDQ/CDR0000043253

http://purl.bioontology.org/ontology/PDQ/CDR0000038450

http://purl.bioontology.org/ontology/PDQ/CDR0000354220

http://purl.bioontology.org/ontology/PDQ/CDR0000042461

http://purl.bioontology.org/ontology/PDQ/CDR0000042524

http://purl.bioontology.org/ontology/PDQ/CDR0000043360

http://purl.bioontology.org/ontology/PDQ/CDR0000346889

http://purl.bioontology.org/ontology/PDQ/CDR0000352174

http://purl.bioontology.org/ontology/PDQ/CDR0000041131

http://purl.bioontology.org/ontology/PDQ/CDR0000271182

http://purl.bioontology.org/ontology/PDQ/CDR0000042476

http://purl.bioontology.org/ontology/PDQ/CDR0000433521

http://purl.bioontology.org/ontology/PDQ/CDR0000042477

http://purl.bioontology.org/ontology/PDQ/CDR0000038324

http://purl.bioontology.org/ontology/PDQ/CDR0000038411

http://purl.bioontology.org/ontology/PDQ/CDR0000344407

http://purl.bioontology.org/ontology/PDQ/CDR0000425598

http://purl.bioontology.org/ontology/PDQ/CDR0000269243

http://purl.bioontology.org/ontology/PDQ/CDR0000042064

http://purl.bioontology.org/ontology/PDQ/CDR0000037949

http://purl.bioontology.org/ontology/PDQ/CDR0000043341

http://purl.bioontology.org/ontology/PDQ/CDR0000042705

http://purl.bioontology.org/ontology/PDQ/CDR0000041374

http://purl.bioontology.org/ontology/PDQ/CDR0000041762

http://purl.bioontology.org/ontology/PDQ/CDR0000269128

http://purl.bioontology.org/ontology/PDQ/CDR0000386169

http://purl.bioontology.org/ontology/PDQ/CDR0000042125

http://purl.bioontology.org/ontology/PDQ/CDR0000373802

http://purl.bioontology.org/ontology/PDQ/CDR0000041448

http://purl.bioontology.org/ontology/PDQ/CDR0000037864

http://purl.bioontology.org/ontology/PDQ/CDR0000041781

http://purl.bioontology.org/ontology/PDQ/CDR0000038633

http://purl.bioontology.org/ontology/PDQ/CDR0000039442

http://purl.bioontology.org/ontology/PDQ/CDR0000041301

http://purl.bioontology.org/ontology/PDQ/CDR0000042871

http://purl.bioontology.org/ontology/PDQ/CDR0000038068

http://purl.bioontology.org/ontology/PDQ/CDR0000038314

http://purl.bioontology.org/ontology/PDQ/CDR0000407529

http://purl.bioontology.org/ontology/PDQ/CDR0000305824

http://purl.bioontology.org/ontology/PDQ/CDR0000038089

http://purl.bioontology.org/ontology/PDQ/CDR0000042850

http://purl.bioontology.org/ontology/PDQ/CDR0000041372

http://purl.bioontology.org/ontology/PDQ/CDR0000043038

http://purl.bioontology.org/ontology/PDQ/CDR0000041611

http://purl.bioontology.org/ontology/PDQ/CDR0000041981

http://purl.bioontology.org/ontology/PDQ/CDR0000387808

http://purl.bioontology.org/ontology/PDQ/CDR0000042499

http://purl.bioontology.org/ontology/PDQ/CDR0000038127

http://purl.bioontology.org/ontology/PDQ/CDR0000038094

http://purl.bioontology.org/ontology/PDQ/CDR0000335284

http://purl.bioontology.org/ontology/PDQ/CDR0000041993

http://purl.bioontology.org/ontology/PDQ/CDR0000043547

http://purl.bioontology.org/ontology/PDQ/CDR0000038152

http://purl.bioontology.org/ontology/PDQ/CDR0000040463

http://purl.bioontology.org/ontology/PDQ/CDR0000038696

http://purl.bioontology.org/ontology/PDQ/CDR0000042054

http://purl.bioontology.org/ontology/PDQ/CDR0000038405

http://purl.bioontology.org/ontology/PDQ/CDR0000344408

http://purl.bioontology.org/ontology/PDQ/CDR0000043088

http://purl.bioontology.org/ontology/PDQ/CDR0000041177

http://purl.bioontology.org/ontology/PDQ/CDR0000355722

http://purl.bioontology.org/ontology/PDQ/CDR0000043063

http://purl.bioontology.org/ontology/PDQ/CDR0000041206

http://purl.bioontology.org/ontology/PDQ/CDR0000041302

http://purl.bioontology.org/ontology/PDQ/CDR0000043321

http://purl.bioontology.org/ontology/PDQ/CDR0000041774

http://purl.bioontology.org/ontology/PDQ/CDR0000041453

http://purl.bioontology.org/ontology/PDQ/CDR0000041280

http://purl.bioontology.org/ontology/PDQ/CDR0000037905

http://purl.bioontology.org/ontology/PDQ/CDR0000038847

http://purl.bioontology.org/ontology/PDQ/CDR0000037966

http://purl.bioontology.org/ontology/PDQ/CDR0000041417

http://purl.bioontology.org/ontology/PDQ/CDR0000043059

http://purl.bioontology.org/ontology/PDQ/CDR0000041232

http://purl.bioontology.org/ontology/PDQ/CDR0000341119

http://purl.bioontology.org/ontology/PDQ/CDR0000329881

http://purl.bioontology.org/ontology/PDQ/CDR0000043637

http://purl.bioontology.org/ontology/PDQ/CDR0000038344

http://purl.bioontology.org/ontology/PDQ/CDR0000038217

http://purl.bioontology.org/ontology/PDQ/CDR0000438667

http://purl.bioontology.org/ontology/PDQ/CDR0000042525

http://purl.bioontology.org/ontology/PDQ/CDR0000356027

http://purl.bioontology.org/ontology/PDQ/CDR0000038317

http://purl.bioontology.org/ontology/PDQ/CDR0000041888

http://purl.bioontology.org/ontology/PDQ/CDR0000041170

http://purl.bioontology.org/ontology/PDQ/CDR0000038856

http://purl.bioontology.org/ontology/PDQ/CDR0000041514

http://purl.bioontology.org/ontology/PDQ/CDR0000038525

http://purl.bioontology.org/ontology/PDQ/CDR0000041371

http://purl.bioontology.org/ontology/PDQ/CDR0000038586

http://purl.bioontology.org/ontology/PDQ/CDR0000038513

http://purl.bioontology.org/ontology/PDQ/CDR0000042003

http://purl.bioontology.org/ontology/PDQ/CDR0000041898

http://purl.bioontology.org/ontology/PDQ/CDR0000038547

http://purl.bioontology.org/ontology/PDQ/CDR0000041127

http://purl.bioontology.org/ontology/PDQ/CDR0000041156

http://purl.bioontology.org/ontology/PDQ/CDR0000038504

http://purl.bioontology.org/ontology/PDQ/CDR0000041965

http://purl.bioontology.org/ontology/PDQ/CDR0000041532

http://purl.bioontology.org/ontology/PDQ/CDR0000037931

http://purl.bioontology.org/ontology/PDQ/CDR0000306448

http://purl.bioontology.org/ontology/PDQ/CDR0000041989

http://purl.bioontology.org/ontology/PDQ/CDR0000341120

http://purl.bioontology.org/ontology/PDQ/CDR0000041275

http://purl.bioontology.org/ontology/PDQ/CDR0000042078

http://purl.bioontology.org/ontology/PDQ/CDR0000041235

http://purl.bioontology.org/ontology/PDQ/CDR0000043684

http://purl.bioontology.org/ontology/PDQ/CDR0000038364

http://purl.bioontology.org/ontology/PDQ/CDR0000041157

http://purl.bioontology.org/ontology/PDQ/CDR0000042516

http://purl.bioontology.org/ontology/PDQ/CDR0000039082

http://purl.bioontology.org/ontology/PDQ/CDR0000043465

http://purl.bioontology.org/ontology/PDQ/CDR0000305852

http://purl.bioontology.org/ontology/PDQ/CDR0000438793

http://purl.bioontology.org/ontology/PDQ/CDR0000363810

http://purl.bioontology.org/ontology/PDQ/CDR0000038180

http://purl.bioontology.org/ontology/PDQ/CDR0000041649

http://purl.bioontology.org/ontology/PDQ/CDR0000043020

http://purl.bioontology.org/ontology/PDQ/CDR0000038343

C1516260

C1524092

C0079083

C1516255

C1516254

C1516257

C4082332

C1516253

C0729066

C0591953

C1516252

C1516261

C1516258

C1516262

C1516256

C1516259

2017-03-29

A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1282" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1282" NCI Thesaurus)

19314

1796

TRD

C1282

CDR0000039176

241240

Drug/agent

carboplatin

T109

T121