Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

bleomycin sulfate

Synonyms

bleomycini sulfas

Definitions

A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C312" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C312" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039139

altLabel

bleomycini sulfas

blexane

Blanoxan

Bleocin

Bleolem

Bleo-S

Oil Bleo

Bleo-cell

bleomycin sulfas

bleomycin sulphate

CAS Registry

9041-93-4

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041983

http://purl.bioontology.org/ontology/PDQ/CDR0000040417

http://purl.bioontology.org/ontology/PDQ/CDR0000039773

http://purl.bioontology.org/ontology/PDQ/CDR0000039700

http://purl.bioontology.org/ontology/PDQ/CDR0000039113

http://purl.bioontology.org/ontology/PDQ/CDR0000039370

http://purl.bioontology.org/ontology/PDQ/CDR0000041583

http://purl.bioontology.org/ontology/PDQ/CDR0000040864

http://purl.bioontology.org/ontology/PDQ/CDR0000040590

http://purl.bioontology.org/ontology/PDQ/CDR0000039686

http://purl.bioontology.org/ontology/PDQ/CDR0000039528

http://purl.bioontology.org/ontology/PDQ/CDR0000043553

http://purl.bioontology.org/ontology/PDQ/CDR0000040802

http://purl.bioontology.org/ontology/PDQ/CDR0000039562

http://purl.bioontology.org/ontology/PDQ/CDR0000043052

http://purl.bioontology.org/ontology/PDQ/CDR0000040239

http://purl.bioontology.org/ontology/PDQ/CDR0000041909

http://purl.bioontology.org/ontology/PDQ/CDR0000039322

http://purl.bioontology.org/ontology/PDQ/CDR0000040889

http://purl.bioontology.org/ontology/PDQ/CDR0000039471

http://purl.bioontology.org/ontology/PDQ/CDR0000038582

http://purl.bioontology.org/ontology/PDQ/CDR0000040867

http://purl.bioontology.org/ontology/PDQ/CDR0000042590

http://purl.bioontology.org/ontology/PDQ/CDR0000040503

http://purl.bioontology.org/ontology/PDQ/CDR0000040395

http://purl.bioontology.org/ontology/PDQ/CDR0000043106

http://purl.bioontology.org/ontology/PDQ/CDR0000039397

http://purl.bioontology.org/ontology/PDQ/CDR0000039378

http://purl.bioontology.org/ontology/PDQ/CDR0000042037

http://purl.bioontology.org/ontology/PDQ/CDR0000039098

http://purl.bioontology.org/ontology/PDQ/CDR0000039463

http://purl.bioontology.org/ontology/PDQ/CDR0000039611

http://purl.bioontology.org/ontology/PDQ/CDR0000041693

http://purl.bioontology.org/ontology/PDQ/CDR0000042930

http://purl.bioontology.org/ontology/PDQ/CDR0000041805

http://purl.bioontology.org/ontology/PDQ/CDR0000039401

http://purl.bioontology.org/ontology/PDQ/CDR0000042041

http://purl.bioontology.org/ontology/PDQ/CDR0000357354

http://purl.bioontology.org/ontology/PDQ/CDR0000040787

http://purl.bioontology.org/ontology/PDQ/CDR0000038574

http://purl.bioontology.org/ontology/PDQ/CDR0000040866

http://purl.bioontology.org/ontology/PDQ/CDR0000039520

http://purl.bioontology.org/ontology/PDQ/CDR0000042269

http://purl.bioontology.org/ontology/PDQ/CDR0000040244

http://purl.bioontology.org/ontology/PDQ/CDR0000039387

http://purl.bioontology.org/ontology/PDQ/CDR0000040401

http://purl.bioontology.org/ontology/PDQ/CDR0000039685

http://purl.bioontology.org/ontology/PDQ/CDR0000039977

http://purl.bioontology.org/ontology/PDQ/CDR0000042016

http://purl.bioontology.org/ontology/PDQ/CDR0000042946

http://purl.bioontology.org/ontology/PDQ/CDR0000039374

http://purl.bioontology.org/ontology/PDQ/CDR0000042224

http://purl.bioontology.org/ontology/PDQ/CDR0000042080

http://purl.bioontology.org/ontology/PDQ/CDR0000041508

http://purl.bioontology.org/ontology/PDQ/CDR0000039391

http://purl.bioontology.org/ontology/PDQ/CDR0000042661

http://purl.bioontology.org/ontology/PDQ/CDR0000039381

http://purl.bioontology.org/ontology/PDQ/CDR0000040453

http://purl.bioontology.org/ontology/PDQ/CDR0000038873

http://purl.bioontology.org/ontology/PDQ/CDR0000039619

http://purl.bioontology.org/ontology/PDQ/CDR0000315772

http://purl.bioontology.org/ontology/PDQ/CDR0000039399

http://purl.bioontology.org/ontology/PDQ/CDR0000040470

http://purl.bioontology.org/ontology/PDQ/CDR0000039445

http://purl.bioontology.org/ontology/PDQ/CDR0000040283

http://purl.bioontology.org/ontology/PDQ/CDR0000039406

http://purl.bioontology.org/ontology/PDQ/CDR0000039377

http://purl.bioontology.org/ontology/PDQ/CDR0000042161

http://purl.bioontology.org/ontology/PDQ/CDR0000041317

http://purl.bioontology.org/ontology/PDQ/CDR0000039613

http://purl.bioontology.org/ontology/PDQ/CDR0000042461

http://purl.bioontology.org/ontology/PDQ/CDR0000041423

http://purl.bioontology.org/ontology/PDQ/CDR0000041062

http://purl.bioontology.org/ontology/PDQ/CDR0000040334

http://purl.bioontology.org/ontology/PDQ/CDR0000042940

http://purl.bioontology.org/ontology/PDQ/CDR0000042268

http://purl.bioontology.org/ontology/PDQ/CDR0000039702

http://purl.bioontology.org/ontology/PDQ/CDR0000038443

http://purl.bioontology.org/ontology/PDQ/CDR0000041421

http://purl.bioontology.org/ontology/PDQ/CDR0000043259

http://purl.bioontology.org/ontology/PDQ/CDR0000040803

http://purl.bioontology.org/ontology/PDQ/CDR0000040154

http://purl.bioontology.org/ontology/PDQ/CDR0000040922

http://purl.bioontology.org/ontology/PDQ/CDR0000042055

http://purl.bioontology.org/ontology/PDQ/CDR0000043683

http://purl.bioontology.org/ontology/PDQ/CDR0000039465

http://purl.bioontology.org/ontology/PDQ/CDR0000039682

http://purl.bioontology.org/ontology/PDQ/CDR0000041288

http://purl.bioontology.org/ontology/PDQ/CDR0000039311

http://purl.bioontology.org/ontology/PDQ/CDR0000041692

http://purl.bioontology.org/ontology/PDQ/CDR0000040895

http://purl.bioontology.org/ontology/PDQ/CDR0000039701

http://purl.bioontology.org/ontology/PDQ/CDR0000040865

http://purl.bioontology.org/ontology/PDQ/CDR0000041650

http://purl.bioontology.org/ontology/PDQ/CDR0000039359

http://purl.bioontology.org/ontology/PDQ/CDR0000039618

http://purl.bioontology.org/ontology/PDQ/CDR0000040082

http://purl.bioontology.org/ontology/PDQ/CDR0000041369

http://purl.bioontology.org/ontology/PDQ/CDR0000039372

http://purl.bioontology.org/ontology/PDQ/CDR0000039349

http://purl.bioontology.org/ontology/PDQ/CDR0000361549

http://purl.bioontology.org/ontology/PDQ/CDR0000039385

http://purl.bioontology.org/ontology/PDQ/CDR0000040398

http://purl.bioontology.org/ontology/PDQ/CDR0000039612

http://purl.bioontology.org/ontology/PDQ/CDR0000042511

http://purl.bioontology.org/ontology/PDQ/CDR0000041422

http://purl.bioontology.org/ontology/PDQ/CDR0000038461

http://purl.bioontology.org/ontology/PDQ/CDR0000040868

http://purl.bioontology.org/ontology/PDQ/CDR0000040936

http://purl.bioontology.org/ontology/PDQ/CDR0000040074

http://purl.bioontology.org/ontology/PDQ/CDR0000043418

http://purl.bioontology.org/ontology/PDQ/CDR0000039368

http://purl.bioontology.org/ontology/PDQ/CDR0000422413

http://purl.bioontology.org/ontology/PDQ/CDR0000315771

http://purl.bioontology.org/ontology/PDQ/CDR0000037980

http://purl.bioontology.org/ontology/PDQ/CDR0000042931

http://purl.bioontology.org/ontology/PDQ/CDR0000042685

http://purl.bioontology.org/ontology/PDQ/CDR0000039355

cui

C1511218

C1449826

C0701921

C1527247

C1511216

C0005739

C1449823

C1511217

Date last modified

2018-01-09

definition

A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C312" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C312" NCI Thesaurus)

Legacy PDQ ID

176

LT

TRD

NCI ID

C312

notation

CDR0000039139

ORIG STY

Drug/agent

prefLabel

bleomycin sulfate

tui

T116

T195

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Delete Mapping To Ontology Source
http://purl.jp/bio/4/id/200906057872503852 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4018135 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4018135 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/15660006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/15660006 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C312 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C312 NCIT LOOM
http://purl.bioontology.org/ontology/SNMI/C-C1332 SNMI CUI
http://stirdf.jst.go.jp/id/200907003285942135 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146472 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146472 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/1621 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/1621 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_34582 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_34582 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_34582 CHEBI LOOM
http://purl.bioontology.org/ontology/SNMI/C-78021 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-78021 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D001761 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001761 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001761 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001761 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D001761 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000178893 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/15660006 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/002661 NDDF CUI