Preferred Name |
donepezil hydrochloride |
|
Synonyms |
1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride |
|
Definitions |
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2603" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2603" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000038109 |
|
altLabel |
1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine Hydrochloride E-2020 Aricept |
|
CAS Registry |
120011-70-3 142057-77-0 |
|
Component of | ||
cui |
C0527315 C0287816 C0771848 |
|
Date last modified |
2017-06-02 |
|
definition |
The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2603" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2603" NCI Thesaurus) |
|
Legacy PDQ ID |
10662 |
|
LT |
TRD |
|
NCI ID |
C2603 |
|
notation |
CDR0000038109 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
donepezil hydrochloride |
|
tui |
T109 T121 |