loading...| Preferred Name |
aminolevulinic acid |
|
| Synonyms |
d-amino-levulinic acid delta aminolevulinic acid 5-aminolevulinic acid 5-amino-4-oxopentanoic acid amino-levulinic acid 5-ALA 5-aminolaevulinic acid delta-aminolevulinic acid |
|
| Definitions |
A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C234" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C234" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000791850 |
|
| altLabel |
d-amino-levulinic acid delta aminolevulinic acid 5-aminolevulinic acid 5-amino-4-oxopentanoic acid amino-levulinic acid 5-ALA 5-aminolaevulinic acid delta-aminolevulinic acid |
|
| CAS Registry |
106-60-5 |
|
| cui |
C0002563 |
|
| DATE FIRST PUBLISHED |
2018-01-08 |
|
| Date last modified |
2018-01-08 |
|
| definition |
A topically administered metabolic precursor of protoporphyrin IX. After topical administration, aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C234" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C234" NCI Thesaurus) |
|
| NCI ID |
C234 |
|
| notation |
CDR0000791850 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
aminolevulinic acid |
|
| tui |
T116 T123 T121 |