loading...| Preferred Name |
certolizumab pegol |
|
| Synonyms |
PHA-738144 |
|
| Definitions |
A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and conjugated to polyethylene glycol (PEG), with anti-inflammatory activity. Upon administration, certolizumab binds to TNF-alpha and prevents the interaction of this cytokine with endogenous cell surface receptors, thereby rendering TNF-alpha inactive and inhibiting TNF-mediated inflammatory responses. TNF-alpha is a protein involved in inflammation, cell survival, and apoptosis. Pegylation of certolizumab allows for an improved pharmacokinetic profile. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80972" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C80972" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000791843 |
|
| altLabel |
PHA-738144 Cimzia CDP 870 CZP CDP870 |
|
| CAS Registry |
428863-50-7 |
|
| cui |
C1172157 C1872109 C2343521 C3463840 |
|
| DATE FIRST PUBLISHED |
2018-01-08 |
|
| Date last modified |
2018-01-08 |
|
| definition |
A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and conjugated to polyethylene glycol (PEG), with anti-inflammatory activity. Upon administration, certolizumab binds to TNF-alpha and prevents the interaction of this cytokine with endogenous cell surface receptors, thereby rendering TNF-alpha inactive and inhibiting TNF-mediated inflammatory responses. TNF-alpha is a protein involved in inflammation, cell survival, and apoptosis. Pegylation of certolizumab allows for an improved pharmacokinetic profile. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80972" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C80972" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C80972 |
|
| notation |
CDR0000791843 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
certolizumab pegol |
|
| tui |
T116 T129 T121 |