loading...| Preferred Name |
cefoxitin sodium |
|
| Synonyms |
Mefoxin |
|
| Definitions |
The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28915" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28915" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000787118 |
|
| altLabel |
Mefoxin Pacetin |
|
| CAS Registry |
33564-30-6 |
|
| cui |
C4733542 C0700446 C0701380 |
|
| DATE FIRST PUBLISHED |
2017-02-23 |
|
| Date last modified |
2017-02-23 |
|
| definition |
The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28915" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28915" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C28915 |
|
| notation |
CDR0000787118 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
cefoxitin sodium |
|
| tui |
T109 T195 T121 |