loading...| Preferred Name |
lidocaine hydrochloride ophthalmic gel |
|
| Synonyms |
lidocaine HCl ophthalmic gel |
|
| Definitions |
An ophthalmic gel formulation containing the synthetic amide-type anesthetic lidocaine, with potential analgesic activity. Upon ophthalmic application, the active ingredient lidocaine binds to and blocks voltage-gated sodium channels in neuronal cell membranes. Lidocaine-mediated stabilization of neuronal membranes inhibits the initiation and conduction of nerve impulses, which numbs the nerves, prevents the trigemino-cardiac reflex and produces a reversible local anesthesia. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C132682" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C132682" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000787102 |
|
| altLabel |
lidocaine HCl ophthalmic gel Akten |
|
| CAS Registry |
73-78-9 |
|
| cui |
C4330544 C2369991 |
|
| DATE FIRST PUBLISHED |
2017-02-22 |
|
| Date last modified |
2017-06-13 |
|
| definition |
An ophthalmic gel formulation containing the synthetic amide-type anesthetic lidocaine, with potential analgesic activity. Upon ophthalmic application, the active ingredient lidocaine binds to and blocks voltage-gated sodium channels in neuronal cell membranes. Lidocaine-mediated stabilization of neuronal membranes inhibits the initiation and conduction of nerve impulses, which numbs the nerves, prevents the trigemino-cardiac reflex and produces a reversible local anesthesia. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C132682" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C132682" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C132682 |
|
| notation |
CDR0000787102 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
lidocaine hydrochloride ophthalmic gel |
|
| tui |
T109 T200 T121 |