loading...| Preferred Name |
vortioxetine hydrobromide |
|
| Synonyms |
Trintellix |
|
| Definitions |
A hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125653" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C125653" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000778329 |
|
| altLabel |
Trintellix 1-(2-((2,4-dimethylphenyl)sulfanyl)phenyl)piperazine monohydrobromide piperazine, 1-(2-((2,4-dimethylphenyl)thio)phenyl)-, hydrobromide (1:1) Brintellix |
|
| CAS Registry |
960203-27-4 |
|
| cui |
C3667607 C4087086 C3667599 |
|
| DATE FIRST PUBLISHED |
2016-01-25 |
|
| Date last modified |
2016-05-17 |
|
| definition |
A hydrobromide salt form of vortioxetine, a serotonin (5-HT) modulator and stimulator (SMS), with antidepressant activity. Vortioxetine inhibits the reuptake of serotonin and norepinephrine from the synaptic cleft and acts variably as a serotonin receptor agonist (5-HT1A), partial agonist (5-HT1B) or antagonist (5-HT3, 5-HT1D and 5-HT7). It is not clear how this agent's purported multimodal mechanism of action contributes to its antidepressant effect; however, it is presumed to increase the synaptic availability of serotonin and norepinephrine. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125653" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C125653" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C125653 |
|
| notation |
CDR0000778329 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
vortioxetine hydrobromide |
|
| tui |
T109 T121 |