loading...| Preferred Name |
meclofenamate sodium |
|
| Synonyms |
meclonax |
|
| Definitions |
The sodium salt form of meclofenamate, an anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Meclofenamate sodium inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of meclofenamate sodium. Meclofenamate sodium also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47597" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47597" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000772302 |
|
| altLabel |
meclonax benzoic Acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt Meclomen sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate |
|
| CAS Registry |
6385-02-0 |
|
| cui |
C0025041 C0728758 |
|
| DATE FIRST PUBLISHED |
2015-05-18 |
|
| Date last modified |
2015-05-18 |
|
| definition |
The sodium salt form of meclofenamate, an anthranilic acid and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Meclofenamate sodium inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of meclofenamate sodium. Meclofenamate sodium also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47597" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47597" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47597 |
|
| notation |
CDR0000772302 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
meclofenamate sodium |
|
| tui |
T109 T121 |