loading...| Preferred Name |
paromomycin sulfate |
|
| Synonyms |
humycin sulfate |
|
| Definitions |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47652" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47652" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000769609 |
|
| altLabel |
humycin sulfate paramomycin sulfate Humatin aminosidine sulfate D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, Sulfate(salt) |
|
| CAS Registry |
1263-89-4 |
|
| cui |
C0733821 C0205881 |
|
| DATE FIRST PUBLISHED |
2015-02-25 |
|
| Date last modified |
2015-09-15 |
|
| definition |
The sulfate salt form of paromomycin, a structural derivative of neomycin, an aminoglycoside antibiotic with amebicidal and bactericidal effects against predominantly aerobic gram-negative bacteria. Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed by cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47652" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47652" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47652 |
|
| notation |
CDR0000769609 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
paromomycin sulfate |
|
| tui |
T109 T195 |