loading...| Preferred Name |
sugammadex sodium |
|
| Synonyms |
Bridion Org 25969 |
|
| Definitions |
The sodium salt form of the biologically inert, selective relaxant binding agent (SRBA) sugammadex, a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade. Sugammadex binds rocuronium, vecuronium, and to a lesser extent pancuronium. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78123" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C78123" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000768866 |
|
| altLabel |
Bridion Org 25969 |
|
| CAS Registry |
343306-79-6 |
|
| cui |
C2350811 C1122937 C2699711 |
|
| DATE FIRST PUBLISHED |
2015-02-05 |
|
| Date last modified |
2015-04-23 |
|
| definition |
The sodium salt form of the biologically inert, selective relaxant binding agent (SRBA) sugammadex, a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade. Sugammadex binds rocuronium, vecuronium, and to a lesser extent pancuronium. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78123" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C78123" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C78123 |
|
| notation |
CDR0000768866 |
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| ORIG STY |
Drug/agent |
|
| prefLabel |
sugammadex sodium |
|
| tui |
T109 T121 |