loading...| Preferred Name |
glycopyrrolate |
|
| Synonyms |
glycopyrronium bromide |
|
| Definitions |
A synthetic quaternary ammonium that is an anticholinergic agent with antispasmodic activity. Glycopyrrolate competitively binds to peripheral muscarinic receptors in the autonomic effector cells of, and inhibits cholinergic transmission in smooth muscle, cardiac muscle, the sinoatrial (SA) node, the atrioventricular (AV) node, exocrine glands and in the autonomic ganglia. Blockage of cholinergic transmission, in smooth muscle cells located in the gastrointestinal tract and the bladder, causes smooth muscle relaxation and prevents the occurrence of painful spasms. In addition, glycopyrrolate inhibits the release of gastric, pharyngeal, tracheal, and bronchial secretions. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29078" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29078" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000764369 |
|
| altLabel |
glycopyrronium bromide Robinul pyrrolidinium, 3-((cyclopentylhydroxyphenylacetyl)oxy)-1,1-dimethyl-, bromide |
|
| CAS Registry |
51186-83-5 |
|
| cui |
C0592075 C0017970 C4082411 |
|
| DATE FIRST PUBLISHED |
2014-09-03 |
|
| Date last modified |
2014-09-17 |
|
| definition |
A synthetic quaternary ammonium that is an anticholinergic agent with antispasmodic activity. Glycopyrrolate competitively binds to peripheral muscarinic receptors in the autonomic effector cells of, and inhibits cholinergic transmission in smooth muscle, cardiac muscle, the sinoatrial (SA) node, the atrioventricular (AV) node, exocrine glands and in the autonomic ganglia. Blockage of cholinergic transmission, in smooth muscle cells located in the gastrointestinal tract and the bladder, causes smooth muscle relaxation and prevents the occurrence of painful spasms. In addition, glycopyrrolate inhibits the release of gastric, pharyngeal, tracheal, and bronchial secretions. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29078" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29078" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29078 |
|
| notation |
CDR0000764369 |
|
| NSC Code |
251252 251251 250836 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
glycopyrrolate |
|
| tui |
T109 T121 |