loading...| Preferred Name |
mebendazole |
|
| Synonyms |
Ovex |
|
| Definitions |
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47595" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47595" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000743306 |
|
| altLabel |
Ovex (5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester R 17635 Vermox Methyl 5-benzoyl benzimidazole-2-carbamate |
|
| CAS Registry |
31431-39-7 |
|
| cui |
C0699951 C0069693 C0025023 C2949739 |
|
| DATE FIRST PUBLISHED |
2012-11-27 |
|
| Date last modified |
2016-01-12 |
|
| definition |
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47595" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47595" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47595 |
|
| notation |
CDR0000743306 |
|
| NSC Code |
184849 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
mebendazole |
|
| tui |
T109 T131 T121 |