loading...| Preferred Name |
mycophenolic acid |
|
| Synonyms |
MPA |
|
| Definitions |
An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C673" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C673" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000732227 |
|
| altLabel |
MPA 4-hexenoic acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)- Lilly-68618 Ly 68618 4-hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)- acide mycophenolique acidum mycophenolicum acido micofenolico Myfortic |
|
| CAS Registry |
24280-93-1 |
|
| cui |
C0026933 C1527314 C1620923 |
|
| DATE FIRST PUBLISHED |
2012-04-18 |
|
| Date last modified |
2012-04-18 |
|
| definition |
An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C673" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C673" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C673 |
|
| notation |
CDR0000732227 |
|
| NSC Code |
129185 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
mycophenolic acid |
|
| tui |
T109 T195 T121 |