loading...| Preferred Name |
tocilizumab |
|
| Synonyms |
RoActemra |
|
| Definitions |
A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. Il-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders and certain types of cancers. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84217" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84217" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000713832 |
|
| altLabel |
RoActemra R-1569 immunoglobulin G1, anti-(human interleukin 6 receptor) (human-mouse monoclonal MRA heavy chain), disulfide with human-mouse monoclonal MRA kappa chain dimer Actemra MRA |
|
| CAS Registry |
375823-41-9 |
|
| cui |
C3272237 C1609165 C2830231 C2740854 |
|
| DATE FIRST PUBLISHED |
2011-10-03 |
|
| Date last modified |
2011-10-04 |
|
| definition |
A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. Il-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders and certain types of cancers. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84217" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84217" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C84217 |
|
| notation |
CDR0000713832 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
tocilizumab |
|
| tui |
T116 T129 T121 |