loading...| Preferred Name |
phenelzine sulfate |
|
| Synonyms |
2-phenylethylhydrazine sulphate 2-phenylethylhydrazine hydrogen sulphate Nardil |
|
| Definitions |
A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47668" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47668" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000686546 |
|
| altLabel |
2-phenylethylhydrazine sulphate 2-phenylethylhydrazine hydrogen sulphate Nardil |
|
| CAS Registry |
156-51-4 |
|
| cui |
C0701388 C0031393 |
|
| DATE FIRST PUBLISHED |
2010-09-30 |
|
| Date last modified |
2010-09-30 |
|
| definition |
A hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47668" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47668" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47668 |
|
| notation |
CDR0000686546 |
|
| NSC Code |
170957 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
phenelzine sulfate |
|
| tui |
T109 T121 |