loading...| Preferred Name |
tiotropium bromide monohydrate |
|
| Synonyms |
6.Beta.,7.Beta.-Epoxy-3.Beta.-Hydroxy-8-Methyl-1.Alpha.H,5.Alpha.H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate |
|
| Definitions |
The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61974" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61974" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000682857 |
|
| altLabel |
6.Beta.,7.Beta.-Epoxy-3.Beta.-Hydroxy-8-Methyl-1.Alpha.H,5.Alpha.H-Tropanium Bromide, Di-2-Thienylglycolate Monohydrate Spiriva 1,4-Dihydro-3,5-Diiodo-1-Methyl-4-Oxopyridine-2,6-Dicarboxylic Acid |
|
| cui |
C1579389 C0905678 |
|
| DATE FIRST PUBLISHED |
2010-08-03 |
|
| Date last modified |
2011-03-11 |
|
| definition |
The monohydrate bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a long-acting muscarinic receptor antagonist, with bronchodilating activity. Upon inhalation, tiotropium binds to and blocks mainly muscarinic M3 receptors located on smooth muscle cells, thereby preventing smooth muscle contraction Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61974" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61974" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C61974 |
|
| notation |
CDR0000682857 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
tiotropium bromide monohydrate |
|
| tui |
T109 T121 |