loading...| Preferred Name |
aminophylline |
|
| Synonyms |
ammophyllin |
|
| Definitions |
A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47393" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47393" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000682624 |
|
| altLabel |
ammophyllin theophyline ethylenediamine Phyllocontin 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1) Truphylline |
|
| CAS Registry |
317-34-0 |
|
| cui |
C0723940 C0002575 C0722625 |
|
| DATE FIRST PUBLISHED |
2010-08-30 |
|
| Date last modified |
2010-07-27 |
|
| definition |
A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47393" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47393" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47393 |
|
| notation |
CDR0000682624 |
|
| NSC Code |
7919 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
aminophylline |
|
| tui |
T109 T121 |