loading...| Preferred Name |
cinacalcet hydrochloride |
|
| Synonyms |
Mimpara Sensipar N-[1(R)-(1-Naphthyl)ethyl]-N-[3-[3-(trifluoromethyl)phenyl]propyl]amine hydrochloride |
|
| Definitions |
The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47450" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47450" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000662071 |
|
| altLabel |
Mimpara Sensipar N-[1(R)-(1-Naphthyl)ethyl]-N-[3-[3-(trifluoromethyl)phenyl]propyl]amine hydrochloride |
|
| cui |
C2981184 C1435704 C1260199 |
|
| DATE FIRST PUBLISHED |
2009-12-16 |
|
| Date last modified |
2010-06-06 |
|
| definition |
The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47450" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47450" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47450 |
|
| notation |
CDR0000662071 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
cinacalcet hydrochloride |
|
| tui |
T109 T121 |