loading...| Preferred Name |
perindopril erbumine |
|
| Synonyms |
S-9490-3 Aceon 1H-indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-,(2S-(1(R*(R*))2alpha,3abeta,7abeta))-, compound with 2-methyl-2-propanamine(1:1) MCN-A-2833-109 perindopril tert-butylamine Coversyl |
|
| Definitions |
The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47666" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47666" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000660818 |
|
| altLabel |
S-9490-3 Aceon 1H-indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-,(2S-(1(R*(R*))2alpha,3abeta,7abeta))-, compound with 2-methyl-2-propanamine(1:1) MCN-A-2833-109 perindopril tert-butylamine Coversyl |
|
| CAS Registry |
82834-16-0 |
|
| cui |
C0752280 C0244718 C0678178 C2987572 C0875950 |
|
| DATE FIRST PUBLISHED |
2009-12-01 |
|
| Date last modified |
2016-01-28 |
|
| definition |
The tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril erbumine is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47666" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47666" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47666 |
|
| notation |
CDR0000660818 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
perindopril erbumine |
|
| tui |
T109 T121 |