loading...| Preferred Name |
dabrafenib |
|
| Synonyms |
Tafinlar benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro- GSK-2118436A GSK2118436 BRAF inhibitor GSK2118436 |
|
| Definitions |
An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82386" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82386" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000641977 |
|
| altLabel |
Tafinlar benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro- GSK-2118436A GSK2118436 BRAF inhibitor GSK2118436 |
|
| cui |
C2826139 C3644555 C3467876 |
|
| DATE FIRST PUBLISHED |
2009-04-29 |
|
| Date last modified |
2014-01-14 |
|
| definition |
An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82386" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82386" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C82386 |
|
| notation |
CDR0000641977 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
dabrafenib |
|
| tui |
T109 T121 |