loading...| Preferred Name |
losartan potassium |
|
| Synonyms |
2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, monopotassium salt |
|
| Definitions |
The potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29165" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29165" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000640981 |
|
| altLabel |
2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, monopotassium salt Cozaar |
|
| CAS Registry |
124750-99-8 |
|
| cui |
C0591301 C0700492 |
|
| DATE FIRST PUBLISHED |
2009-04-17 |
|
| Date last modified |
2010-11-01 |
|
| definition |
The potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29165" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29165" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C29165 |
|
| notation |
CDR0000640981 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
losartan potassium |
|
| tui |
T109 T121 |