loading...| Preferred Name |
asparaginase Erwinia chrysanthemi |
|
| Synonyms |
krisantaspaasi asparaginase-Erwinia Erwinaze krisantaspas Erwinase cristantaspase crisantaspasum Erwinia L-asparginase |
|
| Definitions |
An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C64260" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C64260" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000601044 |
|
| altLabel |
krisantaspaasi asparaginase-Erwinia Erwinaze krisantaspas Erwinase cristantaspase crisantaspasum Erwinia L-asparginase |
|
| CAS Registry |
9015-68-3 |
|
| cui |
C0591457 C3248039 C3255208 |
|
| DATE FIRST PUBLISHED |
2008-07-15 |
|
| Date last modified |
2011-12-09 |
|
| definition |
An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C64260" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C64260" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C64260 |
|
| notation |
CDR0000601044 |
|
| NSC Code |
106977 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
asparaginase Erwinia chrysanthemi |
|
| tui |
T116 T126 T121 |