loading...| Preferred Name |
memantine hydrochloride |
|
| Synonyms |
1-amino-3,5-dimethyladamantane Hydrochloride |
|
| Definitions |
The hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47601" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47601" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000579596 |
|
| altLabel |
1-amino-3,5-dimethyladamantane Hydrochloride Ebixia Namenda |
|
| CAS Registry |
41100-52-1 |
|
| cui |
C4721676 C1330412 C0771988 |
|
| DATE FIRST PUBLISHED |
2007-11-29 |
|
| Date last modified |
2008-03-12 |
|
| definition |
The hydrochloride salt of memantine, a low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47601" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47601" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47601 |
|
| notation |
CDR0000579596 |
|
| NSC Code |
102290 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
memantine hydrochloride |
|
| tui |
T109 T121 |