loading...| Preferred Name |
cefmetazole sodium |
|
| Synonyms |
|
|
| Definitions |
The sodium salt of the second-generation, semi-synthetic, beta-lactam cephalosporin cefmetazole with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs) and prevents the crosslinking of peptidoglycan, which may result in the inhibition of cell wall synthesis, the loss of cell wall integrity, and bacterial cell wall rupture. PBPs are transpeptidases that are responsible for peptidoglycan crosslinking. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65298" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65298" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000564415 |
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| CAS Registry |
56796-39-5 56796-20-4 |
|
| cui |
C0700470 |
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| DATE FIRST PUBLISHED |
2007-08-23 |
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| Date last modified |
2010-03-28 |
|
| definition |
The sodium salt of the second-generation, semi-synthetic, beta-lactam cephalosporin cefmetazole with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs) and prevents the crosslinking of peptidoglycan, which may result in the inhibition of cell wall synthesis, the loss of cell wall integrity, and bacterial cell wall rupture. PBPs are transpeptidases that are responsible for peptidoglycan crosslinking. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65298" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65298" NCI Thesaurus) |
|
| NCI ID |
C65298 |
|
| notation |
CDR0000564415 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
cefmetazole sodium |
|
| tui |
T109 T195 |