loading...| Preferred Name |
efalizumab |
|
| Synonyms |
|
|
| Definitions |
A humanized IgG1 monoclonal antibody directed against CD11a, the alpha subunit of human leukocyte-function-associated antigen type 1 (LFA-1), with immunosuppressant activity. Efalizumab binds to CD11a, which is expressed on all leukocytes, resulting in a reduction in the cell surface expression of CD11a. In addition, this agent inhibits the binding of LFA-1 to intercellular adhesion molecule-1 (ICAM-1), resulting in the inhibition of leukocyte adherence and the suppression of cell-mediated immunity. LFA-1 binding to ICAM-1 is involved in the activation of T lymphocytes, adhesion ofT lymphocytes to endothelial cells, and migration of T lymphocytes to sites of inflammation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68831" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68831" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000553413 |
|
| cui |
C1174995 |
|
| DATE FIRST PUBLISHED |
2007-06-04 |
|
| Date last modified |
2007-10-22 |
|
| definition |
A humanized IgG1 monoclonal antibody directed against CD11a, the alpha subunit of human leukocyte-function-associated antigen type 1 (LFA-1), with immunosuppressant activity. Efalizumab binds to CD11a, which is expressed on all leukocytes, resulting in a reduction in the cell surface expression of CD11a. In addition, this agent inhibits the binding of LFA-1 to intercellular adhesion molecule-1 (ICAM-1), resulting in the inhibition of leukocyte adherence and the suppression of cell-mediated immunity. LFA-1 binding to ICAM-1 is involved in the activation of T lymphocytes, adhesion ofT lymphocytes to endothelial cells, and migration of T lymphocytes to sites of inflammation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68831" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68831" NCI Thesaurus) |
|
| NCI ID |
C68831 |
|
| notation |
CDR0000553413 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
efalizumab |
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| tui |
T116 T129 T121 |