loading...| Preferred Name |
emtricitabine |
|
| Synonyms |
2(1H)-pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)- |
|
| Definitions |
A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47509" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47509" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000540668 |
|
| altLabel |
2(1H)-pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)- (-)-2'-deoxy-5-fluoro-3'-thiacytidine FTC Emtriva coviracil |
|
| CAS Registry |
143491-57-0 |
|
| cui |
C0877876 C1259670 C0909839 C0909841 |
|
| DATE FIRST PUBLISHED |
2007-04-02 |
|
| Date last modified |
2011-04-12 |
|
| definition |
A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5'-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3'-OH group). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47509" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47509" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47509 |
|
| notation |
CDR0000540668 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
emtricitabine |
|
| tui |
T114 T121 |