loading...| Preferred Name |
ofatumumab |
|
| Synonyms |
Arzerra |
|
| Definitions |
A fully human, high-affinity IgG1 monoclonal antibody directed against the B cell CD20 cell surface antigen with potential antineoplastic activity. Ofatumumab binds specifically to CD20 on the surfaces of B cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B cells overexpressing CD20. The CD20 antigen, found on over 90% of B cells, B cell lymphomas, and other B cells of lymphoid tumors of B cell origin, is a non-glycosylated cell surface phosphoprotein that acts as a calcium ion channel; it is exclusively expressed on B cells during most stages of B cell development. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66952" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66952" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000530015 |
|
| altLabel |
Arzerra 2F2 HuMax-CD20 GSK1841157 |
|
| cui |
C4732982 C2724188 C1541395 C2919053 C1832027 |
|
| DATE FIRST PUBLISHED |
2007-01-16 |
|
| Date last modified |
2015-12-04 |
|
| definition |
A fully human, high-affinity IgG1 monoclonal antibody directed against the B cell CD20 cell surface antigen with potential antineoplastic activity. Ofatumumab binds specifically to CD20 on the surfaces of B cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B cells overexpressing CD20. The CD20 antigen, found on over 90% of B cells, B cell lymphomas, and other B cells of lymphoid tumors of B cell origin, is a non-glycosylated cell surface phosphoprotein that acts as a calcium ion channel; it is exclusively expressed on B cells during most stages of B cell development. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66952" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66952" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C66952 |
|
| notation |
CDR0000530015 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ofatumumab |
|
| tui |
T116 T129 T121 |