loading...| Preferred Name |
fondaparinux sodium |
|
| Synonyms |
Arixtra |
|
| Definitions |
The sodium salt form of fondaparinux, a synthetic glucopyranoside with antithrombotic activity. Fondaparinux sodium selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47539" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47539" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000510285 |
|
| altLabel |
Arixtra decasodium salt alpha-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-beta-D-glucopyranuronosyl(1-4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-2-O-sulfo-alpha-L-idopyranuronosyl-(1-4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate) |
|
| CAS Registry |
114870-03-0 |
|
| cui |
C1099665 C1099664 |
|
| DATE FIRST PUBLISHED |
2006-09-23 |
|
| definition |
The sodium salt form of fondaparinux, a synthetic glucopyranoside with antithrombotic activity. Fondaparinux sodium selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47539" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47539" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47539 |
|
| notation |
CDR0000510285 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
fondaparinux sodium |
|
| tui |
T109 T121 |