loading...| Preferred Name |
ondansetron hydrochloride |
|
| Synonyms |
GR-C507/75 |
|
| Definitions |
The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48007" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48007" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000489533 |
|
| altLabel |
GR-C507/75 GR 38032F Zofran SN-307 |
|
| CAS Registry |
99614-01-4 |
|
| cui |
C0733435 C0733437 C0206046 C0700478 C0733434 |
|
| DATE FIRST PUBLISHED |
2006-06-09 |
|
| Date last modified |
2015-06-05 |
|
| definition |
The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48007" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48007" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C48007 |
|
| notation |
CDR0000489533 |
|
| NSC Code |
665799 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ondansetron hydrochloride |
|
| tui |
T109 T121 |