loading...| Preferred Name |
fluphenazine hydrochloride |
|
| Synonyms |
Prolixin |
|
| Definitions |
The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47995" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47995" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000487523 |
|
| altLabel |
Prolixin Permitil |
|
| CAS Registry |
146-56-5 |
|
| cui |
C0722557 C0033390 C0700567 |
|
| DATE FIRST PUBLISHED |
2006-06-02 |
|
| Date last modified |
2006-05-30 |
|
| definition |
The hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47995" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47995" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C47995 |
|
| notation |
CDR0000487523 |
|
| NSC Code |
179197 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
fluphenazine hydrochloride |
|
| tui |
T109 T121 |