loading...| Preferred Name |
recombinant thyrotropin alfa |
|
| Synonyms |
Thyrogen |
|
| Definitions |
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61322" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61322" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000481277 |
|
| altLabel |
Thyrogen |
|
| cui |
C2587204 C0876183 |
|
| DATE FIRST PUBLISHED |
2006-04-20 |
|
| Date last modified |
2006-07-05 |
|
| definition |
A recombinant form of the human anterior pituitary glycoprotein thyroid stimulating hormone (TSH) with use in the diagnostic setting. With an amino acid sequence identical to that of human TSH, thyrotropin alfa binds to TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer cells, stimulating iodine uptake and organification, synthesis and secretion of thyroglobulin (Tg), triiodothyronine (T3), and thyroxine (T4). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61322" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61322" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C61322 |
|
| notation |
CDR0000481277 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
recombinant thyrotropin alfa |
|
| tui |
T125 T116 T121 |